Copenhagen study on Male Reproductive Health

DEER

Developmental Effects of Environment on Reproduction

For publications related to the Copenhagen Study on Male Reproductive Health, see here

 

 

In Denmark, all young men, except those suffering from severe or chronic diseases (<15%), are required to attend a medical examination before they may be considered for military service.

 

In collaboration with the military health authority, young men attending these medical examinations in the greater Copenhagen area in Denmark are asked to participate in The Male Reproductive Health Study. Those men who consented to participate were examined at the Department of Growth and Reproduction at Rigshospitalet, Until now, more than 5000 young men have been included in the study.

For details on the examination, and samples taken, see the column to the left.

 

Inclusion criteria

The young men are invited irrespective of whether they were declared fit for military service.

Place of residence should be in the greater Copenhagen area

Both the young men and their mothers should be born and raised in Denmark.

 

Ethical aspects

The study was approved by ethical committees of the Capital Region (RegionH) and in accordance with the Helsinki II declaration. All participants gave their informed consent.

 

Principal investigator

Senior scientist and Consultant Niels J°rgensen

 

Investigators

Anne-Grethe Andersen MD, PhD

Camilla Asklund MD, PhD

Inge Ahlmann Olesen MD

Loa Nordkap MD

Martin Blomberg Jensen MD

Mette Holm MD, PhD

Peter Christiansen MD

Tina Kold Jensen MD, PhD, Prof

Ulla Nordstr÷m Joensen MD

 

 

 

The study gathers the following information:

 

Physical examination

Height

Weight

Degree of masculinization

External genitals

Testicular size

Testicular ultrasound

Gynaecomastia

 

Semen samples

Produced after a minimum of 48 hours of ejaculation abstinence time.

Sperm concentration

Total sperm count

Motility

Morphology

CYP-24A1

Cholesterol

Phthalates

 

Blood samples

FSH and LH

Testosterone

Estradiol

SHBG

Inhibin B

INSL3

IGF-1 and IGFBP3

Albumin

Cholesterol

Calcium

Alcaline phosphatase

PTH

25-OH-vitamin D

Immunoglobulin E

DNA and RNA isolation Genetic polymorphisms (androgen receptor variations, IGF polymorphisms, SHOX, R501X, 2282del4)

Whole genome SNP analyses (Affymetrix)

PCBs

PFCs

 

Urine sample

Parabens

Phthalates

Bisphenol A

 

Questionnaire

Previous health and growth Socio-economic factors

Lifestyle factors

Diet